Table 1.
Distribution of ACAT-1 in Normal Human Tissues
| Tissues and cells | Immunoreactivity |
|---|---|
| Liver | |
| Hepatocytes | ++ |
| Kupffer cells | +++ |
| Sinusoidal endothelia | − |
| Intrahepatic bile duct | + |
| Adrenal glands | |
| Adrenal cortex | +++ |
| Adrenal medulla | − |
| Gonads | |
| Leidig/granulosa cells | ++ |
| Stromal cells | − |
| Digestive tract | |
| Esophagus | |
| Squamous epithelia | − |
| Esophageal glands | ++ |
| Stomach | |
| Foveolar epithelium | − |
| Fundic glands | ++ |
| Small intestine | |
| Mucosal epithelial cells | ++ |
| Large intestine | |
| Mucosal epithelial cells | − |
| Respiratory system | |
| Alveolar epithelia | ++ |
| Bronchial epithelia | ++ |
| Alveolar macrophages | +++ |
| Cardiovascular system | |
| Cardiomyocytes | + |
| Endothelial cells | − |
| Smooth muscle cells | + |
| Endocrine system | |
| Pituitary gland | + |
| Thyroid gland | |
| Follicular epithelial cells | ++ |
| Nervous system | |
| Neurons | ++ |
| Glial cells | − |
| Myentric ganglia | ++ |
| Kidney | |
| Epithelial cells of proximal and distal tubules | ++ |
| Glomeruli | − |
| Pancreas | |
| Exocrine glands | ++ |
| Langerhans islet cells | − |
| Duct epithelia | + |
| Urinary tract | |
| Transitional epithelial cells | ++ |
| Immune system | |
| Lymphocytes (lymph nodes, spleen, Peyer’s patches) | − |
| Macrophages (liver, lungs, kidneys) | +++ |
+++, strongly positive; ++, positive; +, slightly positive; −, not detected.