Table 1.
Correlation between histoclinical markers and Nectin-4 expression determined by IHC
| Characteristics | N° of patients (%) | P-value | ||
| Nectin4 negative (N=39) 68.4% | Nectin4 positive (N=18) 31.6% | |||
| Age | <50 | 5 (14) | 4 (29) | NS |
| >50 | 31 (86) | 10 (71) | ||
| Histological type | Ductal | 10 (26) | 16 (89) | <0.0001 |
| Lobular | 29 (74) | 2 (11) | ||
| SBR grade | I | 9 (25) | 3 (21) | NS |
| II | 17 (47) | 6 (43) | ||
| III | 10 (28) | 5 (36) | ||
| Axillary lymph node st. | Negative | 19 (53) | 6 (43) | NS |
| Positive | 17 (47) | 8 (57) | ||
| EGFR | Negative | 31 (94) | 7 (54) | 0.0012 |
| Positive | 2 (6) | 6 (46) | ||
| ERBB2 status | 0-1 | 34 (94) | 10 (71) | 0.0245 |
| 2-3 | 2 (6) | 4 (29) | ||
| Ki67 | Negative | 23 (79) | 7 (50) | 0.05 |
| Positive | 6 (21) | 7 (50) | ||
| P53 status | Negative | 33 (97) | 7 (50) | <0.0001 |
| Positive | 1 (3) | 7 (50) | ||
| P-cadherin | Negative | 25 (74) | 4 (29) | 0.0029 |
| Positive | 9 (26) | 11 (71) | ||
| BCL2 | Negative | 2 (6) | 6 (43) | 0.0025* |
| Positive | 30 (94) | 8 (57) | ||
| Estrogen receptor st. | Negative | 0 (0) | 7 (50) | <0.0001* |
| Positive | 37 (100) | 7 (50) | ||
| GATA3 | Negative | 3 (9) | 6 (60) | 0.0004* |
| Positive | 31 (91) | 4 (40) | ||
| Progesterone receptor st. | Negative | 8 (24) | 8 (57) | 0.0247* |
| Positive | 26 (76) | 6 (43) | ||
* Negative correlation with Nectin-4 expression