Figure 11.
Immuno-chemotherapy of CL caused by L. braziliensis in Brazil. Double-blind controlled trial of Mayrink's vaccine (killed L. amazonensis) plus low dose (8 mg/Kg/d) Sb+5 vs. low dose Sb+5. Patients received daily injections of the combination or drug alone for 10 days followed by 10-day rest (one cycle). All patients (47/47) were cured in the combination group after 4 cycles (80 days) vs. 4/47 in the chemotherapy alone group. The non-responders were rescued with full dose antimony. (Adopted from Machado-Pinto et al. Int. J. Dermat. 2002; 41:73-8.)