Figure 13.

Immunotherapy of CL lesions in macaque monkeys. Systemic administration of oligo-deoxy-nucleotide (ODN) class D/A limits the size of lesions following an intradermal infection with L. major. Importantly, the reduced morbidity was not associated with a reduction in long-term immunity, as such treated macaques were still protected following a secondary challenge. This suggests a potential role for CpG ODN in L. major treatment. These findings support the development of clinical studies to assess the use of CpG ODN types D/A as immunoprotective and therapeutic agents. (From Flyn B. et al Infect.& Immun. 73:4948, 2005 with permission)