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Response to topical treatment with different buparvaquones (BPQ). BALB/c mice were infected with 2 × 106 L. major J118 promastigotes and 20 daily topical application began 3 days post-infection. Both a BPQ hydrous gel and a BPQ water-in-oil (w/o) emulsion significantly reduced both parasite burden (P < 0.05, 22 days post infection; as determined by real time PCR) and lesion size compared to the untreated control; P < 0.0001, 13 days post start of treatment, (adopted from T. Garnier).
