Table 3.
Structural prediction accuracy of Dynalign with the M constraint and the new constraint, and for single sequence prediction over 2000 random tRNA pairs.
| Dynalign | ||||||
|---|---|---|---|---|---|---|
| New constraint | M constraint | Single Sequence Prediction | ||||
| + | - | + | - | + | - | |
| Sensitivity | 0.926 | 0.873 | 0.923 | 0.866 | 0.874 | 0.764 |
| PPV | 0.925 | 0.846 | 0.922 | 0.836 | 0.848 | 0.707 |
Column with '+' refers to Dynalign making use of structural constraints where modified nucleotides that cannot accommodate the canonical A-form helix are forced single-stranded [24].