Table 7.
Percent sequence similarity | ||||||
---|---|---|---|---|---|---|
20–40 | 40–60 | 60–80 | 80–100 | 0–100 | ||
Dynalign new constraint | Sens | 0.895 | 0.903 | 0.914 | 0.909 | 0.907 |
PPV | 0.838 | 0.824 | 0.821 | 0.785 | 0.821 | |
Dynalign M constraint | Sens | 0.892 | 0.901 | 0.912 | 0.909 | 0.905 |
PPV | 0.837 | 0.821 | 0.815 | 0.786 | 0.817 | |
FOLDALIGN | Sens | 0.726 | 0.753 | 0.787 | 0.510 | 0.749 |
PPV | 0.772 | 0.784 | 0.803 | 0.572 | 0.778 | |
StemLoc | Sens | 0.272 | 0.673 | 0.899 | 0.776 | 0.740 |
PPV | 0.652 | 0.805 | 0.901 | 0.826 | 0.840 | |
Consan | Sens | 0.666 | 0.799 | 0.931 | 0.865 | 0.842 |
PPV | 0.671 | 0.761 | 0.817 | 0.722 | 0.775 | |
Single Prediction | Sens | 0.680 | 0.722 | 0.766 | 0.784 | 0.739 |
PPV | 0.603 | 0.632 | 0.672 | 0.673 | 0.647 |
Results are summarized for sequence similarity values ranging from 20% through 100% in steps of 20% and for the overall data set (0 – 100). Dynalign new constraint refers to Dynalign with probabilistic alignment constraints proposed here. Software version numbers and parameters for the algorithms are described in Section 7.6.