Figure 6.

Cumulative effect of the subsystems approach to model generation. (A) Reverse-engineering the reaction network from the S. aureus model into the SEED establishes a database of curated reactions and scenarios that serves as a platform for reaction network generation for other genomes. The pie graphs depict the percentage of the total number of reactions in three existing models that are covered by the current SEED database and the percentage that remains to be curated. (B) The graphs for the H. pylori and L. lactis models assume the curation of both the S. aureus and the E. coli models (see text for details). Data are derived from Additional Files 1 and 3.