Figure 10. Model for RelA/p65 function in AP.

During inflammation in the pancreas, acinar cells undergo apoptotic and necrotic cell death. Cellular constituents are released from injured necrotic acinar cells following stimulation with cerulein. This feature is enhanced when functional RelAp65 is lacking. Increased acinar cell necrosis causes infiltration by mononuclear cells, which are activated to produce cytokines such as IL-6 and TNF-α that cause systemic effects including lung inflammation.