Figure 8. Model depicting Ng participation in postsynaptic signal transduction.

Under resting conditions (low Ca²⁺, low PKC activity), Ng locally traps free CaM and PA. Following glutamate receptor activation [NMDA-R (N-methyl-D-aspartate receptor) and mGlu-R (metabotropic glutamate receptor)], both CaM and PA are released and participate in signal transduction pathways that favour LTP over LTD. AC, adenylylate cyclase; DAG, diacylglycerol; mTOR: mammalian target of rapamycin; NOS, nitric oxide synthase; PP1c, PP1 catalytic subunit.