Figure 1. Alignment of amino acid sequences of C. albicans and E. coli GlcN-6-P synthases.

The linker between the GAH and ISOM domains of E. coli GlcN-6-P synthase and the residues substituted in the recombinant versions of the C. albicans enzyme, constructed for the purpose of the present study, are indicated. Numbering for the C. albicans Gfa1p is shown. White letters on a black background indicate conserved residues. Ca, C. albicans; Ec, E. coli.