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. 2007 Apr 26;404(Pt 1):97–104. doi: 10.1042/BJ20061898

Figure 6. Acute ethanol decreases the release of AEA and glutamate in the nucleus accumbens.

Figure 6

(A) Time course of the effects produced by acute ethanol administration on nucleus accumbens (NAC) microdialysate AEA levels. Administration of 0.75 g of ethanol/kg of body mass (n=6) induced a slight, but non-significant, decrease in dialysate AEA content, whereas 2 g/kg ethanol (n=5) induced a significant reduction in dialysate AEA that persisted for at least 120 min following ethanol (EtOH) administration. Results are means±S.E.M. of the percentage of pre-ethanol baseline AEA concentrations. *P<0.05 as determined by post-hoc analyses following ANOVA (see text for details). (B) Time course of the effects produced by acute ethanol (EtOH) administration on nucleus accumbens microdialysate glutamate levels. Administration of 2 g of ethanol/kg of body mass (n=5) induced a significant decrease in dialysate glutamate (GLU) levels. Results are means±S.E.M. of the percentage of pre-ethanol baseline glutamate concentrations. *P<0.05 as determined by post-hoc analyses following ANOVA (see text for details).