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The influence of methotrexate (MTX) on T cell proliferation. Peripheral blood mononuclear cells were cultured in the presence of tetanus toxoid (circles), Candida albicans (squares) or phytohaemaglutinin (triangles) for 7 days, with or without MTX, at the given concentrations, between days 6 and 7. The resulting number of divided CD4+ T cells (a) and CD4– T cells (b) per well are shown as mean ± s.e.m. of six experiments. *P < 0·05 (*)P = 0·06.
