Fig. 1.

Changes in the total level of circulating immune complexes (CICs) and their relative contents of the IgG, IgA and IgM isotypes, before and after infusions of fresh frozen plasma to one systemic lupus erythematosus (SLE) patient who is both C2- and mannan-binding lectin (MBL)-deficient. Arrows indicate timing of the plasma infusions (4 units on day 1 and 3 units on day 2). The MBL concentration in the patient's blood rose from < 20 µg/l before the infusion to 174 µg/l after the infusion on day 2, and then fell to 63 µg/l on day 4 and was < 20 µg/l on day 6 after the infusion.