Table 2.
Genes more abundantly expressed (2-fold or greater) in H400 oral epithelial cells exposed to P. gingivalis (PG) or F. nucleatum (FN). The higher fold changes for genes induced to a greater degree by either PG or FN are shown with a grey background. GO groupings were determined from data provided by the NetAFFX web-tool for the Affymetrix probe ID number.
| Fold change | |||||
|---|---|---|---|---|---|
| GO annotation | Affymetrix ID | GENE | Gene symbol | PG | FN |
| Immune/Inflammatory/chemotaxis response | 211506_s_at | interleukin 8 | IL8 | 10.2 | 33.08 |
| 210118_s_at | interleukin 1, alpha | IL1A | 10.77 | 17.45 | |
| 202859_x_at | interleukin 8 | IL8 | 9.37 | 15.61 | |
| 220322_at | interleukin 1 family, member 9 | IL1F9 | 3.28 | 14.69 | |
| 205067_at | interleukin 1, beta | IL1B | 5.92 | 9.79 | |
| 39402_at | interleukin 1, beta | IL1B | 5.59 | 9.69 | |
| 211668_s_at | plasminogen activator, urokinase | PLAU | 3.73 | 6.95 | |
| 203828_s_at | interleukin 32 | IL32 | 3.72 | 6.9 | |
| 209774_x_at | chemokine (C-X-C motif) ligand 2 | CXCL2 | 3.25 | 6.77 | |
| 210845_s_at | plasminogen activator, urokinase receptor | PLAUR | 2.61 | 6.45 | |
| 205476_at | chemokine (C-C motif) ligand 20 | CCL20 | 6.39 | 5.7 | |
| 204420_at | FOS-like antigen 1 | FOSL1 | 5.17 | 4.09 | |
| Cell cycle/proliferation/differentiation | 210511_s_at | inhibin, beta A (activin A, activin AB alpha polypeptide) | INHBA | 6.14 | 14.87 |
| 205767_at | epiregulin | EREG | 20.59 | 14.29 | |
| 205239_at | amphiregulin (schwannoma-derived growth factor) | AREG | 8.55 | 8.51 | |
| 203414_at | monocyte to macrophage differentiation-associated | MMD | 2.95 | 4.45 | |
| 202147_s_at | interferon-related developmental regulator 1 | IFRD1 | 2.65 | 3.31 | |
| 200953_s_at | cyclin D2 | CCND2 | 2.59 | 3.15 | |
| 202146_at | interferon-related developmental regulator 1 | IFRD1 | 2.69 | 2.67 | |
| 202934_at | hexokinase 2 | HK2 | 2.63 | 2.58 | |
| 208892_s_at | dual specificity phosphatase 6 | DUSP6 | 3.08 | 2.37 | |
| Protein metabolism/processing | 205180_s_at | a disintegrin and metalloproteinase domain 8 | ADAM8 | 6.85 | 9.84 |
| 203889_at | secretory granule, neuroendocrine protein 1 (7B2 protein) | SCG5 | 4.23 | 6.26 | |
| 202843_at | DnaJ (Hsp40) homolog, subfamily B, member 9 | DNAJB9 | 6.91 | 4.94 | |
| 215009_s_at | SEC31-like 1 (S. cerevisiae) | SEC31L1 | 2.36 | 2.89 | |
| 213262_at | spastic ataxia of Charlevoix-Saguenay (sacsin) | SACS | 4.32 | 2.56 | |
| 217168_s_at | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | HERPUD1 | 2.92 | 2.37 | |
| Signal transduction | 202644_s_at | tumor necrosis factor, alpha-induced protein 3 | TNFAIP3 | 3.01 | 15.01 |
| 202643_s_at | tumor necrosis factor, alpha-induced protein 3 | TNFAIP3 | 3.84 | 13.61 | |
| 203821_at | heparin-binding EGF-like growth factor | HBEGF | 4.37 | 12.12 | |
| 210517_s_at | A kinase (PRKA) anchor protein (gravin) 12 | AKAP12 | 3.25 | 10.58 | |
| 221577_x_at | growth differentiation factor 15 | GDF15 | 3.58 | 2.81 | |
| Apoptosis/Anti-apoptosis | 204614_at | serine (or cysteine)proteinase inhibitor, clade B (ovalbumin), member 2 | SERPINB2 | 3.02 | 7.59 |
| 217997_at | pleckstrin homology-like domain, family A, member 1 | PHLDA1 | 3.77 | 7.11 | |
| 218000_s_at | pleckstrin homology-like domain, family A, member 1 | PHLDA1 | 2.56 | 4.49 | |
| 210538_s_at | baculoviral IAP repeat-containing 3 | BIRC3 | 2.52 | 2.43 | |
| Transcription regulation | 208025_s_at | high mobility group AT-hook 2 /// high mobility group AT-hook 2 | HMGA2 | 3.84 | 5.72 |
| 202936_s_at | SRY (sex determining region Y)-box 9 | SOX9 | 3.2 | 4.71 | |
| 36711_at | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | MAFF | 3.23 | 3.4 | |
| Cell adhesion | 201645_at | tenascin C (hexabrachion) | TNC | 3.12 | 8.47 |
| 203562_at | fasciculation and elongation protein zeta 1 (zygin I) | FEZ1 | 3.21 | 3.68 | |
| Metabolism | 212473_s_at | microtubule associated monoxygenase, calponin and LIM domain containing 2 | MICAL2 | 2.93 | 8.09 |
| 210041_s_at | phosphoglucomutase 3 | PGM3 | 2.79 | 3.53 | |
| Nitric oxide/oxidative stress response | 203946_s_at | arginase, type II | ARG2 | 3.89 | 9.25 |
| 215223_s_at | superoxide dismutase 2, mitochondrial | SOD2 | 2.57 | 4.69 | |
| Autophagy/Cytolosis | 203827_at | WD40 repeat protein Interacting with phospholnositides of 49 kDa | WIPI1 | 3.01 | 3.24 |