Table 3.
Genes decreased in expression (2-fold or greater) in H400 oral epithelial cells exposed to P. gingivalis (PG) or F. nucleatum (FN). Fold changes for genes decreased by a greater degree by either PG or FN are shown with a grey background. GO groupings were determined from data provided by the NetAFFX web-tool for the Affymetrix probe ID number.
| Fold change | |||||
|---|---|---|---|---|---|
| Go annotation | Affymetrix ID | GENE | Gene symbol | PG | FN |
| Protein metabolism/processing/proteolysis | 209596_at | matrix-remodelling associated 5 | MXRA5 | −4.18 | −4.99 |
| 221215_s_at | receptor-interacting serine-threonine kinase 4 | RIPK4 | −3.02 | −4.88 | |
| 213640_s_at | lysyl oxidase | LOX | −6.07 | −4.14 | |
| 205959_at | matrix metalloproteinase 13 (collagenase 3) | MMP13 | −7.34 | −4.02 | |
| 204580_at | matrix metalloproteinase 12 (macrophage elastase) | MMP12 | −9.05 | −3.19 | |
| 204298_s_at | lysyl oxidase | LOX | −6.92 | −3.17 | |
| 214041_x_at | Ribosomal protein L37a | RPL37A | −3.34 | −2.68 | |
| 215446_s_at | lysyl oxidase | LOX | −4.75 | −2.48 | |
| Cell cycle/growth/proliferation | 211607_x_at | epidermal growth factor receptor | EGFR | −2.72 | −8.42 |
| 210984_x_at | epidermal growth factor receptor | EGFR | −2.85 | −7.83 | |
| 204379_s_at | fibroblast growth factor receptor 3 | FGFR3 | −4.34 | −7.48 | |
| 202718_at | insulin-like growth factor binding protein 2, 36 kDa | IGFBP2 | −2.37 | −3.99 | |
| 213413_at | stoned B-like factor | STON1 | −3.39 | −3.78 | |
| 209784_s_at | jagged 2 | JAG2 | −3.01 | −2.5 | |
| 32137_at | jagged 2 | JAG2 | −2.98 | −2.48 | |
| 201141_at | glycoprotein (transmembrane) | GPNMB | −3.29 | −2.46 | |
| Cell adhesion/motility | 209872_s_at | plakophilin 3 | PKP3 | −4.95 | −4.17 |
| 201668_x_at | myristoylated alanine-rich protein kinase C substrate | MARCKS | −4.3 | −3.74 | |
| 211905_s_at | integrin, beta 4 | ITGB4 | −3.11 | −3.33 | |
| 208153_s_at | FAT tumor suppressor homolog 2 | FAT2 | −3.42 | −3.19 | |
| 201107_s_at | thrombospondin 1 | THBS1 | −2.9 | −2.7 | |
| 201107_s_at | thrombospondin 1 | THBS1 | −2.9 | −2.7 | |
| 204989_s_at | integrin, beta 4 | ITGB4 | −3.92 | −2.37 | |
| Epidermis development | 209351_at | keratin 14 | KRT14 | −6.17 | −8.63 |
| 213240_s_at | keratin 4 | KRT4 | −2.59 | −4.89 | |
| 222242_s_at | kallikrein 5 | KLK5 | −2.51 | −3.38 | |
| 204734_at | keratin 15 | KRT15 | −3.47 | −2.67 | |
| 207935_s_at | keratin 13 | KRT13 | −2.71 | −2.49 | |
| Fatty acid/lipid metabolism | 211548_s_at | hydroxyprostaglandin dehydrogenase 15-(NAD) | HPGD | −3.26 | −3.69 |
| 211708_s_at | stearoyl-CoA desaturase (delta-9-desaturase) | SCD | −2.8 | −3.38 | |
| 203980_at | fatty acid binding protein 4, adipocyte | FABP4 | −5.72 | −2.79 | |
| 203914_x_at | hydroxyprostaglandin dehydrogenase 15-(NAD) | HPGD | −2.57 | −2.75 | |
| Nervous system signalling/development | 205413_at | chromosome 11 open reading frame 8 | MPPED2 | −4.76 | −5.19 |
| 200648_s_at | glutamate-ammonia ligase (glutamine synthase) | GLUL | −2.75 | −3.78 | |
| 217202_s_at | glutamate-ammonia ligase (glutamine synthase) | GLUL | −3.07 | −3.46 | |
| Transcription regulation | 207826_s_at | inhibitor of DNA binding 3 | ID3 | −4.01 | −3.61 |
| 210892_s_at | general transcription factor II, I | GTF21 | −2.67 | −3.31 | |
| 212016_s_at | polypyrimidine tract binding protein 1 | PTBP1 | −2.45 | −3.18 | |
| Transport | 206165_s_at | chloride channel, calcium activated, family member 2 | CLCA2 | −3.94 | −3.89 |
| Unclassified | 207761_s_at | DKFZP586A0522 protein | METTL7A | −2.9 | −5.47 |
| 221805_at | neurofilament, light polypeptide 68 kDa | NEFL | −2.43 | −3.57 | |
| 208156_x_at | epiplakin 1 III epiplakin 1 | EPPK1 | −3.27 | −3.41 | |
| 213075_at | olfactomedin-like 2A | OLFML2A | −2.83 | −2.99 | |
| 208978_at | cysteine-rich protein 2 | CRIP2 | −3.22 | −2.77 | |
| 213069_at | HEG homolog 1 (zebrafish) | HEG1 | −2.58 | −2.74 | |
| 213100_at | Unc-5 homolog B (C. elegans) | – | −3.71 | −2.51 | |