Fig. 3.
Requirement of T or B cells in delayed-type hypersensitivity (DTH) arthritis. DTH arthritis was induced in C,B-17/lcr-scid (SCID) mice (▴) and the corresponding control C.B-17/lcr-+/+ mice (○) (a), as described in Materials and methods. One day before immunization, the SCID mice were reconstituted with the splenocytes (1 × 107 cells/body) derived from BALB/ c (○) or SCID mice (▴), and then DTH (b) or DTH arthritis (c) was induced, as described in Materials and methods. The severity is represented by the clinical score as described in Materials and methods. The data were expressed as the mean ± s.e.m. of the five mice in each group. The clinical score of control C.B-17/lcr-+/+ or BALB/c mice was significantly different from those of SCID mice (*P < 0·05; **P < 0·01).