Table 1.
DTH | DTH arthritis | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Day 1 | Day 7 | Day 1 | Day 7 | |||||||||
1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | |
Synovial tissues | ||||||||||||
Oedema | ++ | + | ++ | – | – | – | ++ | ++ | +++ | ++ | ++ | ++ |
Congestion and/or haemorrhage | + | – | + | – | – | – | + | – | + | + | + | + |
Presence of debris in the cavity | + | ++ | ++ | + | + | + | +++ | ++ | +++ | +++ | ++ | ++ |
Deposition of fibrin | – | + | ++ | – | – | – | – | + | + | +++ | +++ | +++ |
Infiltration of neutrophils | + | +++ | ++ | + | – | + | ++ | + | ++ | +++ | +++ | +++ |
Infiltration of macrophage cells | – | + | + | – | – | + | + | + | + | + | + | + |
Infiltration of lymphocytes | – | – | – | – | – | – | – | – | – | – | + | – |
Infiltration of blood plasma cells | + | + | + | + | + | + | + | + | + | + | + | + |
Proliferation of fibroblasts | + | + | + | – | – | – | – | + | + | +++ | +++ | +++ |
Proliferation of papilla (villi) | – | + | – | + | + | + | + | – | + | +++ | + | + |
Proliferation of synovial cells | + | + | – | + | + | − | – | – | + | + | + | + |
Bone and cartilage tissues | ||||||||||||
Detatchment of chondrocytes | – | – | – | – | – | – | – | – | – | – | + | + |
Destruction of bone tissues | – | – | – | – | – | – | – | – | – | + | + | – |
Increase in osteoclasts | – | – | – | – | – | – | – | – | – | + | + | + |
Ostitis and/or periostitis | – | – | – | – | – | – | – | – | – | ++ | ++ | +++ |
DTH or DTH arthritis was induced using the same procedure as in Fig. 1. Three mice were killed on days 1 and 7, and histological sections were made. The severity of each inflammatory event in the synovial tissues, bone and cartilage tissues was graded as follows: –, normal; +, slight change; + +, mild change; + + +, severe change.