Table 1.
Histological examination of tarsal joints of delayed-type hypersensitivity (DTH) or DTH arthritis-induced mice.a
| DTH | DTH arthritis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 7 | Day 1 | Day 7 | |||||||||
| 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | |
| Synovial tissues | ||||||||||||
| Oedema | ++ | + | ++ | – | – | – | ++ | ++ | +++ | ++ | ++ | ++ |
| Congestion and/or haemorrhage | + | – | + | – | – | – | + | – | + | + | + | + |
| Presence of debris in the cavity | + | ++ | ++ | + | + | + | +++ | ++ | +++ | +++ | ++ | ++ |
| Deposition of fibrin | – | + | ++ | – | – | – | – | + | + | +++ | +++ | +++ |
| Infiltration of neutrophils | + | +++ | ++ | + | – | + | ++ | + | ++ | +++ | +++ | +++ |
| Infiltration of macrophage cells | – | + | + | – | – | + | + | + | + | + | + | + |
| Infiltration of lymphocytes | – | – | – | – | – | – | – | – | – | – | + | – |
| Infiltration of blood plasma cells | + | + | + | + | + | + | + | + | + | + | + | + |
| Proliferation of fibroblasts | + | + | + | – | – | – | – | + | + | +++ | +++ | +++ |
| Proliferation of papilla (villi) | – | + | – | + | + | + | + | – | + | +++ | + | + |
| Proliferation of synovial cells | + | + | – | + | + | − | – | – | + | + | + | + |
| Bone and cartilage tissues | ||||||||||||
| Detatchment of chondrocytes | – | – | – | – | – | – | – | – | – | – | + | + |
| Destruction of bone tissues | – | – | – | – | – | – | – | – | – | + | + | – |
| Increase in osteoclasts | – | – | – | – | – | – | – | – | – | + | + | + |
| Ostitis and/or periostitis | – | – | – | – | – | – | – | – | – | ++ | ++ | +++ |
a
DTH or DTH arthritis was induced using the same procedure as in Fig. 1. Three mice were killed on days 1 and 7, and histological sections were made. The severity of each inflammatory event in the synovial tissues, bone and cartilage tissues was graded as follows: –, normal; +, slight change; + +, mild change; + + +, severe change.