Table 5.
Frequencies of CBC patients carrying apathogenic DNA-damage repair pathway mutation
| Interval (years) | All CBC patients | Previous RT | No RT | Carriers versus non-carriers | |||||
| n | Percentage | n | Percentage | n | Percentage | OR for CBC after RT | 95% CI | p | |
| 1–5 (n = 66) | 15/66 | 22.7 | 12/49 | 24.5 | 3/16 | 18.8 | 1.41 | 0.34–5.78 | |
| >5 (n = 181) | 36/181 | 19.9 | 29/120 | 24.1 | 7/62 | 11.3 | 2.51 | 1.03–6.10 | 0.049 |
All contralateral breast cancer (CBC) patients, and patients stratified by previous radiation exposure are presented, according to interval between first and second primary breast cancer (less than 5 and more than 5 years). Odds ratio (OR) and 95% confidence interval (CI) are given for mutation carriers versus non-carriers to develop radiation-associated breast cancer. RT, radiation treatment.