Table 2.
Statistics of key gene ontology categories by mechanism of regulation in 728 E2 + ERβ downregulated genes
| Gene function | Percentage total | χ2 p value |
| 'Synergistic' | ||
| Apoptosis | 0% (0/129) | 0.33018 |
| Cell cycle | 0.8% (1/129) | 0.47730 |
| Cell proliferation | 0% (0/129) | 0.53595 |
| DNA replication | 0.8% (1/129) | 0.67051 |
| 'Attenuation' | ||
| Apoptosis | 0.4% (2/492) | 0.40303 |
| Cell cycle | 1.8% (9/492) | 0.11725 |
| Cell proliferation | 0.2% (1/492) | 0.70713 |
| DNA replication | 1.6% (8/492) | 0.00080 |
| 'Antagonistic' | ||
| Apoptosis | 0.9% (1/107) | 0.80404 |
| Cell cycle | 8.4% (6/107) | 0.00077 |
| Cell proliferation | 0.9% (1/107) | 0.22828 |
| DNA replication | 0.9% (1/107) | 0.53640 |
| All genes on array | ||
| Apoptosis | 0.7% (138/18,912) | - |
| Cell cycle | 1.5% (293/18,912) | - |
| Cell proliferation | 0.3% (56/18,912) | - |
| DNA replication | 0.5% (96/18,912) | - |
ERβ, estrogen receptor beta.