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. 2007 May 11;146(2-5):756–772. doi: 10.1016/j.neuroscience.2007.01.067

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© 2007 Elsevier Ltd.

Open Access under CC BY 3.0 license

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Fig. 3 — Activation of bronchopulmonary afferent vagal pathways was not necessary for the effects of Mv-NC on DRI serotonergic neurons. Immunostained products are the same as in Fig. 1. (a) Bar graphs illustrate the mean number (±S.E.M.) of c-Fos-ir nuclei in the AP and SolDL (left) and c-Fos-ir/tryptophan hydroxylase-ir neurons in the DRC and DRI (right) in experiment 4. (b, c) Photomicrographs illustrate c-Fos responses to i.t. Mv-NC or s.c. M. vaccae in M. vaccae–preimmunized mice in the SolDL and AP (b) or the DRI (c) at the 12 h time point. For abbreviations, see Fig. 1 legend. (⇒) c-Fos-immunonegative serotonergic neurons, () c-Fos-immunopositive serotonergic neurons. Scale bar=100 μm b; b (insets), 50 μm; c, 25 μm; c (insets), 12.5 μm. Abbreviations: Mv, s.c. challenge with heat-killed M. vaccae; Sal, s.c. challenge with saline vehicle. For additional abbreviations, see Fig. 1 legend. * P≤0.05, compared with the appropriate M. vaccae–preimmunized, vehicle-injected control group, Fisher’s protected LSD test.

Inline graphic — Activation of bronchopulmonary afferent vagal pathways was not necessary for the effects of Mv-NC on DRI serotonergic neurons. Immunostained products are the same as in Fig. 1. (a) Bar graphs illustrate the mean number (±S.E.M.) of c-Fos-ir nuclei in the AP and SolDL (left) and c-Fos-ir/tryptophan hydroxylase-ir neurons in the DRC and DRI (right) in experiment 4. (b, c) Photomicrographs illustrate c-Fos responses to i.t. Mv-NC or s.c. M. vaccae in M. vaccae–preimmunized mice in the SolDL and AP (b) or the DRI (c) at the 12 h time point. For abbreviations, see Fig. 1 legend. (⇒) c-Fos-immunonegative serotonergic neurons, () c-Fos-immunopositive serotonergic neurons. Scale bar=100 μm b; b (insets), 50 μm; c, 25 μm; c (insets), 12.5 μm. Abbreviations: Mv, s.c. challenge with heat-killed M. vaccae; Sal, s.c. challenge with saline vehicle. For additional abbreviations, see Fig. 1 legend. * P≤0.05, compared with the appropriate M. vaccae–preimmunized, vehicle-injected control group, Fisher’s protected LSD test.