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. 2007 Mar 16;92(11):3960–3967. doi: 10.1529/biophysj.106.099234

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Area per molecule as a function of cholesterol concentration. The averaged cross section area of phospholipid is calculated by where V_c is the chain volume of the lipid (36), and the thickness of the hydrocarbon region is PtP minus twice the length of the glycerol region (from the phosphate to the first methylene of the hydrocarbon chains); the latter is very close to 10 Å (27,33,36). The average area per molecule for the cholesterol-phospholipid mixtures is calculated by The area per cholesterol A_chol is assumed to be constant of x. A value of was taken from monolayer measurements on pure cholesterol (3,37).

Inline graphic — Area per molecule as a function of cholesterol concentration. The averaged cross section area of phospholipid is calculated by where V_c is the chain volume of the lipid (36), and the thickness of the hydrocarbon region is PtP minus twice the length of the glycerol region (from the phosphate to the first methylene of the hydrocarbon chains); the latter is very close to 10 Å (27,33,36). The average area per molecule for the cholesterol-phospholipid mixtures is calculated by The area per cholesterol A_chol is assumed to be constant of x. A value of was taken from monolayer measurements on pure cholesterol (3,37).