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. 2007 Mar 16;92(11):3915–3929. doi: 10.1529/biophysj.106.101956

FIGURE 2.

FIGURE 2

Effect of 1 μM CnErg1 on voltage dependence of activation of hERG channels. (A) Typical example of current traces recorded in the absence (i) and presence (ii) of 1 μM CnErg1 during 4 s depolarizing pulses to voltages in the range +40 mV to −60 mV followed by a 500 ms step to −60 mV. (B) Plot of normalized peak tail currents (see arrows in A) plotted against the voltage of the preceding test pulse in the absence (▴) and presence (□) of 1 μM CnErg1. The line of best fit is the Boltzmann function (see Materials and Methods) giving V0.5 for activation of 15.1 ± 1.6 mV to −1.6 ± 2.9 mV and slope factors of 8.9 ± 0.8 mV and 9.6 ± 1 mV for control and 1 μM CnErg1, respectively (mean ± SE, n = 5).