FIGURE 7.
(A) Typical example of the timecourse of current inhibition during exposure to 100 nM CnErg1. Current values were measured from the peak during the −120 mV step (see voltage protocol in Fig. 1). Dashed and dashed-dotted lines are single exponential functions fitted to the data for the onset and offset of current block. (B) Summary of toxin concentration dependence of the association (k+1, [toxin], •) and dissociation (k−1, □) rate constants for CnErg1 block of hERG currents. Data points show mean ± SE for n = 5–14 experiments and the dashed line shows a straight line of best fit to the association rate constant data at low toxin concentrations. (C) Magnification of the boxed region from panel B showing straight line of best fit to rate constant data at low toxin concentrations.