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Mean changes in hERG current magnitude during wash-on and wash-off of CnErg1 at concentrations ranging from 5 nM to 300 nM. Data points are mean ± SE for normalized current values from n = 5–14 experiments. The lines of best fit are derived from kinetic Scheme 2 using values for k+1, k−1, k+2, and k−2, shown in Table 1.
