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. 2007 Mar 16;92(11):3901–3914. doi: 10.1529/biophysj.106.102400

FIGURE 8.

FIGURE 8

Burst kinetics support an open-state block mechanism. (A) TRPV1 channel burst kinetics. Upper panel shows bursts of openings at 60 mV in the presence of 10 nM capsaicin in a patch containing ∼120 channels. The closed and open channel levels are indicated. Rare openings of a very small conductance channel are also visible. The lower panel shows traces recorded in the same patch and under the same conditions as in the upper panel but in the presence of 250 μM TBA. (B) Burst-length distributions of the patch in (A). The upper panel shows the burst-length distribution in the absence of blocker. The lower panel shows the burst length distribution in 250 μM TBA. The continuous lines are the prediction of the burst length from Scheme 3 with the parameters shown in Table 2.