Table 1.

Effects of drugs on SEPYLRFamide-mediated reduction of ACh-induced current in Helix lucorum neurons

No	Drugs	Amplitude of ACh-current, %	Compared series	Statistical significance
1	Helix saline; n=11	101.00 ± 5.83	–	–
2.1	SEPYLRFamide, 1st application (S1); n=30	57.73 ± 4.04	1	Đ<0.001*
2.2	SEPYLRFamide, 2nd application (S2); n=16	54.21 ± 5.31	2.1	NS
2.3	SEPYLRFamide, 3rd application (S3); n=10	66.87 ± 8.63	2.1	NS
			2.2	NS
3.1	S (before ouabain; control); n=18	51.90 ± 3.94	–	–
3.2	OUABAIN (O)+S; n=18	62.96 ± 5.52	3.1	Đ<0.05
3.3	S (after wash of ouabain); n=15	48.09 ± 5.30	3.2	P<0.05
			3.1	NS
2.1 + 3.1	S1 + S con; n=48	55.54 ± 2.93	1	P<0.001
4	Na (in) + S; n=18	82.38 ± 3.92	2.1	Đ<0.001
5.1	BZ + S1; n=12	72.48 ± 7.29	2.1	P<0.05
			2.1 + 3.1	P<0.05
5.2	BZ + S2; n=7	71.67 ± 6.43	5.1	NS
5.3	BZ + S3; n=5	74.07 ± 7.53	5.2	NS
6.1	BZ + S (before ouabain; control); n=15	76.13 ± 6.70	2.1 + 3.1	P<0.01
6.2	BZ + O + S; n=15	78.15 ± 7.47	6.1	NS
6.3	BZ + S; (after wash of ouabain); n=8	81.96 ± 8.41	6.2	NS
			6.1	NS
5.1 + 6.1	BZ-S1 + BZ-Scon; n=27	74.50 ± 4.98	2.1 + 3.1	P<0.001
7.1	TG + S1; n=13	77.25 ± 7.27	2.1 + 3.1	P<0.01
7.2	TG + S2; n=7	73.40 ± 7.40	7.1	NS
7.3	TG + S3; n=4	66.28 ± 12.88	7.2	NS
8.1	TG + S (before ouabain; control); n=16	67.46 ± 6.08	2.1 + 3.1	P<0.05
8.2	TG + O + S; n=11	68.12 ± 8.50	8.1	NS
8.3	TG + S (after wash of ouabain); n=9	77.89 ± 5.36	8.2	NS
			8.1	NS
7.1 + 8.1	TG-S1 + TG-Scon; n=29	71.85 ± 4.82	2.1 + 3.1	P<0.01
9.1	CPA + S1; n=16	67.26 ± 4.92	2.1 + 3.1	Đ<0.05
9.2	CPA + S2; n=11	55.64 ± 4.59	9.1	NS
			9.1 + 10.1	Đ<0.05
9.3	CPA + S3; n=6	55.68 ± 5.35	9.2	NS
			9.1 + 10.1	Đ<0.05
10.1	CPA + S (before ouabain; control); n=17	70.25 ± 4.52	2.1 + 3.1	Đ<0.05
10.2	CPA + O + S; n=13	85.07 ± 5.92	10.1	Đ<0.05
10.3	CPA + S (after wash of ouabain); n=12	70.51 ± 4.54	10.2	P<0.05
			10.1	NS
9.1 + 10.1	CPA-S1 + CPA-Scon; n=33	68.80 ± 3.29	2.1 + 3.1	P<0.01

Values represent mean ± S.E.M.;

^*Wilcoxon test, NS —nonsignificant.