Table 2.

Chromosome aberrations in HyTcrTg⁺Rag2^−/−Atm^−/− premalignant thymus and spleen^*

Mouse	Genotype	Thymus	Spleen	No. of aberrant metaphases/total analyzed
8046	HyTcrTg+	T(11;9)	T(3;10),T(3;1)	Thymus:
	Rag2−/−	T(2;11),T(11;2)	T(12;14)	2/10 = 20%
	Atm−/−		T(12;15)†	Spleen:
			Rb[T(11;9).4]‡	6/12 = 50%
			Rb[X.Del(X)]
8644	HyTcrTg+	T(12;4)§	Not analyzed	Thymus:
	Rag2−/−	T(12;15;4)¶		8/10 = 80%
	Atm−/−
8645	HyTcrTg+	None	Not analyzed	Thymus:
	Rag2−/−			0/10 = 0%
	Atm+/+

^*Structural aberrations were determined by SKY analysis. Most aberrations were not clonal (see below for exceptions). 

^† This translocation was present in two metaphase cells. 

^‡Rb, Robertsonian translocation (centromere–centromere dicentric). 

^§This translocation was present in four metaphase cells. 

^¶This translocation was present in four metaphase cells.