Figure 1.

Distinct wound locations have specific histology. (A) A typical venous stasis ulcer is shown. Arrows point to the regions from which biopsies were obtained: A, nonhealing edge and B, adjacent, nonulcerated skin. (B) H&E stained biopsies showing epidermis from nonhealing edge (location A); adjacent, nonulcerated skin (location B); (C) H&E stained biopsies showing dermis from nonhealing edge (location A); adjacent, nonulcerated skin (location B). Normal skin is shown on the right panel. (D) Staining with procollagen shows increased intracellular staining of the nonhealing edge (location A) when compared with adjacent, nonulcerated skin (location B). Circles demarcate the location from which enlarged images are shown (insets below). Normal skin is shown on the right panels. Scale bar: 100 μm