Figure 5.

Inhibition of intratumoral vascularization. (A) The importance of intratumoral vascularization was assessed by smooth muscle actin-immunostaining at day 26 postgrafting and quantified (see Materials and Methods). Lanes: 1, AdCO1-injected group; 2, AdK3-injected group; 3, irradiation alone; 4, combination of AdCO1 and irradiation; 5, combination of AdK3 and irradiation. Immunostaining of representative tumors from the AdCO1-injected group (B Right), the AdCO1 + x-ray combination group (B Left), the AdK3-injected group (C Right), and the AdK3 + x-ray combination group (C Left) are shown at the same magnification.