Figure 5.

CFTR chimeric antibody heavy and light chain sequences. (A) The amino acid sequence of the four CFTR antibody light chain VJ exons are aligned with the germ line sequence; amino acid differences are indicated. The adjacent mouse sequences are delineated. (B) Chicken antibodies are diversified by numerous gene conversion events. The location and minimal extent of gene conversion tracts are indicated by open boxes with the potential pseudogene donor indicated above the tract. Nucleotide changes that are not present in any of the pseudogenes are located with an ∗. An insertion is indicated by a ∧. (C) The amino acid sequence of the four CFTR antibody heavy chain VDJ exons are aligned with the germ line sequence; amino acid differences are indicated.