Figure 2.

Old/Tg mice are deficient at learning a rewarded T-maze alternation task (Experiment 1). Mean ± SEM number of days for each group to reach the criterion for learning of at least 5 out of 6 correct responses on 3 consecutive days. There were no differences among young/APP⁻ (solid open bar), young/APP⁺ (hatched open bar), and old/APP⁻ (solid filled bar) groups in days required to reach criterion, or in the percentage of animals in each group that reached criterion. None of the old/APP⁺ mice (hatched filled bar) had reached criterion by the 14-d point, at which the experiment was stopped.