Table 4.
KEGG pathways identified by B. glabrata ESTs
| KEGG categories represented | Enzymesa | Clonesb | |
|---|---|---|---|
| 1 | Metabolism | ||
| 1.1 | Carbohydrate metabolism | ||
| 1.1.1 | Glycolysis/gluconeogenesis | 7 | 12 |
| 1.1.3 | Pentose phosphate pathway | 4 | 5 |
| 1.1.5 | Fructose and mannose metabolism | 1 | 2 |
| 1.1.6 | Galactose metabolism | 2 | 2 |
| 1.1.7 | Ascorbate and aldarate metabolism | 3 | 4 |
| 1.1.8 | Starch and sucrose metabolism | 6 | 12 |
| 1.1.9 | Aminosugars metabolism | 1 | 1 |
| 1.1.11 | Pyruvate metabolism | 4 | 5 |
| 1.1.12 | Glyoxylate and dicarboxylate metabolism | 1 | 1 |
| 1.1.13 | Propanoate metabolism | 2 | 2 |
| 1.1.14 | Butanoate metabolism | 5 | 5 |
| 1.1.17 | Inositol phosphate metabolism | 1 | 1 |
| 1.2 | Energy metabolism | ||
| 1.2.1 | Oxidative phosphorylation | 7 | 7 |
| 1.2.2 | ATP synthesis | 1 | 1 |
| 1.2.4 | Carbon fixation | 3 | 7 |
| 1.2.6 | Methane metabolism | 2 | 2 |
| 1.2.7 | Nitrogen metabolism | 1 | 1 |
| 1.3 | Lipid metabolism | ||
| 1.3.1 | Fatty acid biosynthesis | 1 | 1 |
| 1.3.2 | Fatty acid elongation in mitochondria | 1 | 2 |
| 1.3.3 | Fatty acid metabolism | 2 | 2 |
| 1.3.4 | Synthesis and degradation of ketone bodies | 1 | 1 |
| 1.3.6 | Bile acid biosynthesis | 1 | 1 |
| 1.3.9 | Glycerolipid metabolism | 1 | 1 |
| 1.3.10 | Glycerophospholipid metabolism | 2 | 2 |
| 1.4 | Nucleotide metabolism | ||
| 1.4.1 | Purine metabolism | 6 | 8 |
| 1.4.2 | Pyrimidine metabolism | 3 | 4 |
| 1.5 | Amino acid metabolism | ||
| 1.5.1 | Glutamate metabolism | 2 | 2 |
| 1.5.2 | Alanine and aspartate metabolism | 1 | 1 |
| 1.5.3 | Glycine, serine and threonine metabolism | 4 | 6 |
| 1.5.4 | Methionine metabolism | 1 | 2 |
| 1.5.6 | Valine, leucine and isoleucine degradation | 2 | 2 |
| 1.5.7 | Valine, leucine and isoleucine biosynthesis | 2 | 3 |
| 1.5.8 | Lysine biosynthesis | 1 | 1 |
| 1.5.9 | Lysine degradation | 2 | 2 |
| 1.5.10 | Arginine and proline metabolism | 5 | 7 |
| 1.5.11 | Histidine metabolism | 2 | 3 |
| 1.5.12 | Tyrosine metabolism | 2 | 3 |
| 1.5.13 | Phenylalanine metabolism | 2 | 2 |
| 1.5.14 | Tryptophan metabolism | 5 | 6 |
| 1.5.15 | Phenylalanine, tyrosine and tryptophan biosynthesis | 2 | 3 |
| 1.5.16 | Urea cycle and metabolism of amino groups | 3 | 4 |
| 1.6 | Metabolism of other amino acids | ||
| 1.6.1 | β-alanine metabolism | 3 | 4 |
| 1.6.3 | Aminophosphonate metabolism | 1 | 2 |
| 1.6.4 | Selenoamino acid metabolism | 1 | 2 |
| 1.7 | Glycan biosynthesis and metabolism | ||
| 1.7.1 | N-Glycan biosynthesis | 1 | 1 |
| 1.7.3 | N-Glycan degradation | 1 | 1 |
| 1.7.4 | O-Glycan biosynthesis | 1 | 1 |
| 1.7.12 | Glycosphingolipid metabolism | 1 | 1 |
| 1.8 | Biosynthesis of polyketides and nonribosomal peptides | ||
| 1.8.3 | Biosynthesis of ansamycins | 1 | 1 |
| 1.9 | Metabolism of cofactors and vitamins | ||
| 1.9.3 | Vitamin B6 metabolism | 2 | 2 |
| 1.9.6 | Biotin metabolism | 1 | 1 |
| 1.9.7 | Folate biosynthesis | 3 | 8 |
| 1.9.10 | Porphyrin and chlorophyll metabolism | 3 | 4 |
| 1.9.11 | Ubiquinone biosynthesis | 4 | 4 |
| 1.10 | Biosynthesis of secondary metabolites | ||
| 1.10.4 | Limonene and pinene degradation | 2 | 2 |
| 1.10.6 | Stilbene, coumarine and lignin biosynthesis | 3 | 4 |
| 1.10.8 | Alkaloid biosynthesis I | 1 | 2 |
| 1.10.12 | Streptomycin biosynthesis | 1 | 1 |
| 1.11 | Biodegradation of xenobiotics | ||
| 1.11.4 | γ-hexachlorocyclohexane degradation | 2 | 2 |
| 1.11.5 | 3-chloroacrylic acid degradation | 1 | 2 |
| 1.11.6 | 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation | 1 | 2 |
| 1.11.8 | 1,2-dichloroethane degradation | 1 | 1 |
| 1.11.14 | Fluorene degradation | 2 | 3 |
| 1.11.17 | Benzoate degradation via hydroxylation | 1 | 2 |
| 1.11.18 | Atrazine degradation | 1 | 1 |
| 1.11.20 | 1- and 2-methylnaphthalene degradation | 1 | 2 |
| 2 | Genetic information processing | ||
| 2.1 | Transcription | ||
| 2.1.2 | RNA polymerase | 1 | 1 |
| 2.1.3 | Basal transcription factors | 2 | 2 |
| 2.2 | Translation | ||
| 2.2.2 | Ribosome | 20 | 27 |
| 2.2.3 | Aminoacyl-tRNA biosynthesis | 16 | 35 |
| 2.3 | Folding, sorting and degradation | ||
| 2.3.1 | Protein export | 2 | 3 |
| 2.3.2 | Type II secretion system | 1 | 1 |
| 2.3.7 | Ubiquitin mediated proteolysis | 3 | 4 |
| 2.3.8 | Proteasome | 7 | 11 |
| 3 | Environmental information processing | ||
| 3.1 | Membrane transport | ||
| 3.1.1 | ABC transporters | 15 | 23 |
| 3.2 | Signal transduction | ||
| 3.2.1 | Two-component system | 3 | 3 |
| 3.2.2 | MAPK signalling pathway | 4 | 7 |
| 3.2.3 | Wnt signalling pathway | 6 | 6 |
| 3.2.4 | Notch signalling pathway | 1 | 1 |
| 3.2.6 | TGF-β signalling pathway | 5 | 5 |
| 3.2.9 | Calcium signalling pathway | 10 | 14 |
| 3.2.10 | Phosphatidylinositol signalling system | 2 | 2 |
| 3.3 | Signalling molecules and interaction | ||
| 3.3.1 | Neuroactive ligand–receptor interaction | 17 | 20 |
| 3.3.2 | Cytokine–cytokine receptor interaction | 3 | 3 |
| 3.3.3 | ECM–receptor interaction | 5 | 7 |
| 3.3.4 | Cell adhesion molecules (CAMs) | 25 | 36 |
| 4 | Cellular processes | ||
| 4.1 | Cell motility | ||
| 4.1.3 | Regulation of actin cytoskeleton | 15 | 37 |
| 4.2 | Cell growth and death | ||
| 4.2.1 | Cell cycle | 5 | 5 |
| 4.2.2 | Apoptosis | 6 | 11 |
| 4.3 | Cell communication | ||
| 4.3.1 | Focal adhesion | 13 | 26 |
| 4.3.2 | Adherens junction | 8 | 16 |
| 4.3.3 | Tight junction | 9 | 21 |
| 4.3.4 | Gap junction | 6 | 25 |
| 4.4 | Endocrine system | ||
| 4.4.1 | Insulin signalling pathway | 6 | 8 |
| 4.4.2 | Adipocytokine signalling pathway | 3 | 3 |
| 4.5 | Immune system | ||
| 4.5.1 | Hematopoietic cell lineage | 2 | 2 |
| 4.5.2 | Complement and coagulation cascades | 5 | 7 |
| 4.5.3 | Toll-like receptor signalling pathway | 1 | 1 |
| 4.5.4 | Natural killer cell mediated cytotoxicity | 2 | 2 |
| 4.5.6 | T cell receptor signalling pathway | 2 | 2 |
| 4.5.7 | B cell receptor signalling pathway | 6 | 7 |
| 4.5.9 | Leukocyte transendothelial migration | 7 | 10 |
| 4.8 | Development | ||
| 4.8.2 | Axon guidance | 7 | 10 |
| 4.9 | Behaviour | ||
| 4.9.1 | Circadian rhythm | 3 | 7 |
a
Enzymes—the number of enzymes from each pathway that were identified.
b
Clones—the number of ORESTES clones that identified enzymes.