Table 2.

Clinical characteristics in 30 pediatric patients with recurrent low-grade glioma treated with temozolomide

Characteristic	Patient Data
Period of study	June 1999–August 2005
No. of eligible enrolled patients	30 (Duke 15, CHOP 9, and Beth Israel 6)
Median age at enrollment	10 years (range, 4–18 years)
Sex ratio	21 M/9 F
No. of patients who received prior focal radiotherapy and/or chemotherapy	19
Type of low-grade glioma
Optic pathway glioma	14
Pilocytic astrocytoma	12
Fibrillary astrocytoma	4
No. of patients with NF-1	4

Abbreviations: CHOP, Children’s Hospital of Philadelphia; NF-1, neurofibromatosis type 1.