Table 4.

Selected studies of chemotherapy treatment of progressive low-grade glioma in children and adults

					Response to Chemotherapy
Study Drug	Study Population	Predominant Tumor	No. Pts.	Prior Therapy	CR	PR	SD	PD	Disease Stabilization Rate	Median Duration of Disease Stabilization	Reference
Carboplatin + vincristine	Children	OPG and PA	78	Surgery only	4	22	47	5	94%	36 months	Packer et al. (1997)
Carboplatin	Children	OPG and PA	81	Surgery, chemotherapy, XRT	2	17	15	11	85%	22 months	Gururangan et al. (2002)
TPCV + dibromodulcitol	Children	PA	42	Surgery only	0	15	25	2	95%	33 months	Prados et al. (1997)
Temozolomide	Children	OPG and PA	13	Surgery, chemotherapy, XRT	0	3	6	4	70%	NA	Kuo et al. (2003)
Temozolomide	Children	OPG and PA	26	Surgery, chemotherapy, XRT	0	3	11	12	52%	34 months	Present study
Temozolomide	Adults	OG, FA, OA	29	Surgery only	0	3	25	1	97%	NA	Brada et al. (2003)
Temozolomide	Adults	OG, FA, OA	46	Surgery, chemotherapy, XRT	11	17	16	1	95%	22 months	Quinn et al. (2003)
Temozolomide	Adults	OG, FA, OA	43	Surgery, chemotherapy, XRT	4	16	17	6	86%	9 months	Pace et al. (2003)
Temozolomide	Adults	OG, FA, OA	60	Surgery only.	0	10	45	5	92%	NA	Hoang-Xuan et al.

Abbreviations: CR, complete response; FA, fibrillary astrocytoma; NA, not available; OG, oligodendroglioma; OA, oligoastrocytoma; OPG, optic pathway glioma; PA, pilocytic astrocytoma; PD, progressive disease; PR, partial response; SD, stable disease; TPCV, thioguanine, procarbazine, chloroethyl cyclohexylnitrosourea (lomustine), vincristine; XRT, focal radiotherapy.