Table 2.
Genetic alterations identified in both the benign and the malignant components of the ganglioglioma and candidate genes involved in the initiation or formation of the tumor in these chromosomal regions
| Chromosome No. | Conventional CGH | Array CGH | Candidate Genes |
|---|---|---|---|
| 1 | –1p35-pter, –1p35 | –1p36.3, –1p35 | TP73, DFFB, MYCL1 |
| 3 | No common alterations | –3q13.1 | |
| 4 | –4p16, +4q13–28 | +4q21.3-24 | SEPT11 , CCN1 |
| 5 | No common alterations | –5q13.2, +5q14, –5q31.2, +5q34 | FGF1, RHOBTB3 , GLRX |
| 6 | No common alterations | –6p21.3, –6q24-25.2 | PPP1R2P1 , TAP1 , SOD2 , WTAP |
| 7 | No common alterations | –7q36 | TRIM24 |
| 8 | No common alterations | +8q22.2 | OAZIN |
| 9 | No common alterations | –9p12 | ADFP |
| 14 | No common alterations | –14q21 | RBM25 |
| 15 | No common alterations | +15q12 | RASGRP1 |
| 17 | No common alterations | –17q21.2 | UBTF |
| X | No common alterations | –Xp11.3-11.22 |
Abbreviation: CGH, comparative genomic hybridization.