Table 1.
Frequency of preprogenitor and lineage-committed progenitor cells in mpl+/+ and mpl−/− mice
| Stimulus | Colony type | mpl+/+ | mpl−/− |
|---|---|---|---|
| SCF | Blast | 36 ± 8 | 4 ± 3 |
| Granulocytic | 89 ± 23 | 34 ± 10 | |
| FL + LIF | Blast | 19 ± 2 | 5 ± 5 |
| IL-3 | Blast | 35 ± 13 | 3 ± 3 |
| Granulocytic | 77 ± 14 | 33 ± 3 | |
| GM | 57 ± 14 | 33 ± 13 | |
| Macrophage | 56 ± 14 | 33 ± 3 | |
| Eosinophil | 15 ± 7 | 7 ± 3 | |
| Megakaryocytic | 37 ± 17 | 17 ± 12 |
Frequencies of clonogenic cells are expressed per 105 bone marrow cells. Mean data ± SD from replicate cultures of three 8-week-old mice of each genotype. GM, granulocyte-macrophage.