Table 1.

Host–guest binding affinities and thermodynamic values

Host	Guest	Ka, M−1, UV-Vis	Ka, M−1, ITC	ΔG, kcal/mol, UV-Vis	ΔG, kcal/mol, ITC	ΔH, kcal/mol	TΔS, kcal/mol
1	Acetate	5.3 ± 1.4 × 102	Enthalpically neutral	−3.70 ± 0.16
	Succinate	5.5 ± 1.7 × 103	2.57 ± 0.28 × 103	−5.08 ± 0.19	−4.66 ± 0.07	−0.14 ± 0.04	4.52 ± 0.08
	Glutarate		1.36 ± 0.15 × 103		−4.28 ± 0.07	0.73 ± 0.21	5.01 ± 0.22
	Tricarballate		2.34 ± 0.26 × 103		−4.60 ± 0.07	−1.16 ± 0.33	3.44 ± 0.34
	Tetracarboxylate		1.94 ± 0.21 × 104		−5.86 ± 0.07	−1.95 ± 0.56	3.91 ± 0.56
2	Acetate	3.5 ± 0.3 × 101	1.61 ± 0.18 × 101	−2.11 ± 0.05	−1.65 ± 0.07	1.45 ± 0.16	3.10 ± 0.17
	Succinate	1.7 ± 0.1 × 102	1.15 ± 0.13 × 102	−3.05 ± 0.04	−2.81 ± 0.07	1.01 ± 0.29	3.82 ± 0.30
	Glutarate		1.08 ± 0.12 × 102		−2.78 ± 0.07	1.61 ± 0.46	4.39 ± 0.47
3	Acetate		1.29 ± 0.14 × 101		−1.52 ± 0.05	0.31 ± 0.09	1.83 ± 0.10
	Succinate		3.39 ± 0.37 × 101		−2.09 ± 0.07	−0.16 ± 0.05	1.93 ± 0.09
	Glutarate		5.29 ± 0.58 × 101		−2.36 ± 0.06	0.31 ± 0.09	2.67 ± 0.11