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. 2007 Apr 9;104(16):6800–6805. doi: 10.1073/pnas.0608885104

Fig. 2.

Fig. 2.

Dose response of Dox-induced HuPrP expression in the skeletal muscle of the Tg(HQK) mice. (A) Western blot analysis. (B) Plot of the dose-dependent induction of PrP. The Tg(HQK) mice were treated for 7 days with indicated doses of Dox. Skeletal muscles from an uninduced Tg(HQK) mouse (0 Dox) and brain tissues from a Tg11 mouse and a PrP KO mouse (KO FVB) served as controls. Tg11 is a transgenic mouse line expressing human PrP in the brain at approximately six times that of wild-type FVB mice (Q.K., unpublished data). Twenty micrograms of total protein was loaded for each sample. The blot was probed with mAb 3F4. The Tg(HQK) mice were all in the PrP-null FVB background.