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Cocaine-induced CPP in D2R−/− mice. (A) Time spent in the cocaine-paired compartment during pre- (hatched bars) and postconditioning (black bars) phases in WT and D2R−/− littermates. (B) CPP score [difference in time spent (s) in post- vs. preconditioning phases in the drug-paired compartment]. Treatment effect compared with its control: ∗, P < 0.05; ∗∗, P < 0.001.
