Table 2.

Related^* nonhematologic toxicities, worst by patient (n = 18 patients)

	Grade**
Toxicity	1	2	3	4	5	Total	% Points
Flu-like symptoms
Fever	1					1	(5.6)
Fatigue		4	2			6	(33.3)
Rigors, chills		1				1	(5.6)
Gastrointestinal
Anorexia	1	2				3	(16.7)
Diarrhea			1			1	(5.6)
Dyspepsia/heartburn	1					1	(5.6)
Nausea	3	2				5	(27.8)
Vomiting	1					1	(5.6)
Renal
Urine frequency/urgency	1					1	(5.6)
Neurology
Confusion	1		1			2	(11.1)
Neuropathy-cranial		1				1	(5.6)
Speech impairment			1			1	(5.6)
Memory loss	1					1	(5.6)
Neuropathy-motor		1	1			2	(11.1)
Seizure(s)		1				1	(5.6)
Depressed conscious		2				2	(11.1)
Tremor		2				2	(11.1)
Pain
Headache	1	2				3	(16.7)
Pulmonary
Dyspnea		1				1	(5.6)
Dermatology
Alopecia	2					2	(11.1)
Injection site reaction	1					1	(5.6)
Pruritus	1					1	(5.6)
Rash/desquamation	1					1	(5.6)
Any	9	10	4	0	0	12	(66.7)

^*Considered by investigator to be possibly, probably, or definitely related to protocol treatment.

^**Toxicity graded according to National Cancer Institute Common Toxicity Criteria version 2.0.