Table 4.
Patients | Number Evaluated | AUC mg/h/m | Cmaxng/ml | Vol. Dist. liters/m2 | Half-life h | Clearance liters/m2/h |
---|---|---|---|---|---|---|
1–7 | 7 | Mean 9653.7 | 4046 | 9.4 | 0.6 | 35.9 |
SD 2057.4 | 1325 | 3.8 | 0.1 | 9.7 | ||
8–18 | 11 | Mean | 3201 | 40.2 | ||
SD | 911.2 | 9.1 | ||||
All | 18 | Mean | 3529 | 38.5 | ||
SD | 1135 | 9.3 |
Abbreviations: AUC, area under the curve; Cmax, peak concentration; Vol. Dist., volume of distribution.