Table 4.

Pharmacokinetic results. Mean pharmacokinetic parameters (n = 18 patients)

Patients	Number Evaluated	AUC mg/h/m	Cmaxng/ml	Vol. Dist. liters/m2	Half-life h	Clearance liters/m2/h
1–7	7	Mean 9653.7	4046	9.4	0.6	35.9
		SD 2057.4	1325	3.8	0.1	9.7
8–18	11	Mean	3201			40.2
		SD	911.2			9.1
All	18	Mean	3529			38.5
		SD	1135			9.3

Abbreviations: AUC, area under the curve; C_max, peak concentration; Vol. Dist., volume of distribution.