Fig. 2.

Domain structure of HIF-1α1–6 (shown as HIF-1α–HIF-1α⁴¹⁷), HIF-2α, and HIF-3α1–6. Functional domains are abbreviated as follows: bHLH, basic helix-loop-helix; PAS, Per/Arnt/Sim; PAC, PAS-associated motifs; NAD, N-terminal transactivation domain; ODD, oxygen-dependent domain; CAD, C-terminal activation domain; and LZIP, leucine zipper domain. Position of modified amino acids are indicated as follows: *, hydroxylated proline; @, acetylated lysine;Δ, hydroxylated asparagines. (Adapted from Maynard et al. [2003] and Lee et al. [2004].)