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Replication rates of R3659 and M002 HSV in 4C8 cells. Replication rates were compared in 4C8 mouse glioma cells growing in vitro by infecting cells at 0.1 or 1.0 PFU/cell and harvesting infected cells at 24, 48, 72, or 96 h to recover infectious virus. Mean virus yields in four to eight replicates at each time point were determined by titration on Vero cells and standard deviations determined.
