Fig. 4.

Expression of intracellular FOXP3 in total CD4+ cells. Higher levels of FOXP3 expression in CD4+CD25+ cells were observed in (B) regulatory T cells isolated from tumor tissue (55.1% ± 1.88%; range, 51%–62.4%) versus (A) autologous patient blood (33.4% ± 1.95%; range, 29.7%–38.4%) versus (C) control blood (15.6% ± 0.76%; range, 13.2%–17.1%) (P < 0.01). (D) Comparison of FOXP3 and CD25 expression on Tr in TILs, autologous blood, and peripheral blood of control. Abbreviations: HB, healthy blood; AB, autologous blood; NB, control brain; GB, glioma brain.