Table 1.
Comparison of zidovudine recovery by microdialysis*
| Recovery | ||||||||
|---|---|---|---|---|---|---|---|---|
| Blood | Muscle | Brain | ||||||
| Method (Flow Rate) | N | In Vitro | In Vivo | In Vitro | In Vivo | In Vitro | In Vivo | |
| Zero Net Flux (1μl/min) | 5 | Mean: | 0.79 | 0.40 | 0.66 | 0.26 | 0.67 | 0.15 |
| SD: | 0.11 | 0.29 | 0.12 | 0.11 | 0.06 | 0.07 | ||
| CV (%): | 14 | 72 | 19 | 42 | 9 | 46 | ||
| Retrodialysis (0.5 μl/min) | 3 | Mean: | 0.90 | 0.69 | 0.92 | 0.50 | 0.90 | 0.29 |
| SD: | 0.07 | 0.06 | 0.06 | 0.10 | 0.05 | 0.10 | ||
| CV (%): | 8 | 8 | 7 | 20 | 6 | 32 | ||
Abbreviations used are as follows: CV, coefficient of variation; SD, standard deviation.
*
From Fox et al. (2002b).