Fig. 1.

Growth curves for individual subcutaneous tumors in the first experiment. In vivo efficacy study in which s.c. U-251 MG cell–derived tumors (≈85-mm³ average volume) were injected 4 times with GRN163. Mice received direct intratumoral injections of PBS, Lipofectamine, MM Control, or GRN163 on days 18, 20, 22, and 25 after implantation of the tumor cells. GRN163 and MM Control were given at a dose of 3 nmol per injection in 20 μl total volume.