Figure 6.

Schematic representation of a hypothesis regarding the cellular lesion in ML-IV. Lack of hydrochloric acid secretion by parietal cells that are constantly stimulated by gastrin is accompanied by diversion of the tubulovesicular membranes (TV) into lysosomes. On the right, we show the effect of the lesion on other cell types in ML-IV. Recycling endosomes involved in a deficient plasma membrane-specific function are diverted into lysosomes. 1, H⁺/K⁺-ATPase; 2, ion channels; 3, cytoskeletal elements; 4, kinases involved in plasma membrane activation; 5, kinases and phosphatases involved in the deactivation process; 6, SNAREs; 7, G-proteins; and 8, annexins.