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Absence of PDE4D activity in the lung of PDE4D−/− mice. Lung tissue was dissected from PDE4D+/+, PDE4D+/−, and PDE4D−/− mice and homogenized as described (16). Aliquots of the homogenates were assayed for PDE activity in the absence (total) or presence (RI) of 10 μM rolipram. Data are the mean ± SEM (n = 3–8 mice/genotype, P < 0.05 determined by Student's t test). The number of mice in each group is reported above the bars.
